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Fig. 1 · Structure
Cat. No.
A12732
CAS No.
1373423-53-0
Formula
C24H27N5O2
Mol. Weight
417.5

Documents & Downloads

GSK-J4

Cat. No. A12732 CAS 1373423-53-0

Demethylase Inhibitor

GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF, release).

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Publications for GSK-J4

1 publication citing this product

  1. Guang Bai, .et al. , Epigenetics of Chronic Pain, 2019, Pages 1-48
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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1373423-53-0
Applications Demethylase Inhibitor
Formula C24H27N5O2
Molecular Weight 417.5
SMILES
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

1 publication citing this product

  1. Guang Bai, .et al. , Epigenetics of Chronic Pain, 2019, Pages 1-48

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