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GSK215

Catalog No.: A24687
PROTAC FAK Degrader
GSK215 is a potent and selective PROTAC degrader targeting focal adhesion kinase (FAK) via the VHL E3 ligase. With a pDC50 of 8.4, it induces rapid and sustained degradation of FAK, leading to significant modulation of FAK levels over time. This compound demonstrates an extended pharmacokinetic/pharmacodynamic disconnect, making it a valuable tool for research applications in cancer biology and signaling pathways associated with cell adhesion and migration.
GSK215 2743427-26-9 PROTAC FAK Degrader
Grouped product items
Size Price Stock Qty
1mg
$100.00
In stock
5mg
$260.00
In stock
10mg
$415.00
In stock
25mg
$695.00
In stock
50mg
$945.00
In stock
100mg
$1,240.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGSK215 is a potent and selective PROTAC degrader targeting focal adhesion kinase (FAK) via the VHL E3 ligase. With a pDC50 of 8.4, it induces rapid and sustained degradation of FAK, leading to significant modulation of FAK levels over time. This compound demonstrates an extended pharmacokinetic/pharmacodynamic disconnect, making it a valuable tool for research applications in cancer biology and signaling pathways associated with cell adhesion and migration.
Product Information
Catalog NumA24687
FormulaC50H59F3N10O6S
Molecular Weight985.13
CAS Number2743427-26-9
SMILESO=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC=C(NC4=NC=C(C(F)(F)F)C(NC5=CC=CC=C5C(NC)=O)=C4)C(OC)=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
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Angiogenesis > FAK