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GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ?? 4.1 nM in an assay detecting released CoA.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.34 mL | 116.69 mL | 233.38 mL |
| 0.5 mM | 4.67 mL | 23.34 mL | 46.68 mL |
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21827 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1332331-08-4 |
| Formula | C25H24N4O3 |
| M. Wt | 428.48 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | GSK 2194069, GSK-2194069 |
| SMILES | O=C(N1C[[email protected]](CC2=NNC(N2C3=CC=C(C4=CC=C(OC=C5)C5=C4)C=C3)=O)CC1)C6CC6 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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