GSK2578215A

Catalog No.: A12798

LRRK2 kinase inhibitor

GSK2578215A

GSK2578215A Chemical Structure

CAS NO. 1285515-21-0

GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $60.00

Special Price $54.00

25 mg

Regular Price: $120.00

Special Price $108.00

50 mg

Regular Price: $230.00

Special Price $207.00

100 mg

Regular Price: $400.00

Special Price $360.00

10mM * 1mL in DMSO

Regular Price: $87.00

Special Price $78.30

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively).
Targets
LRRK2 (G2019S) LRRK2 (WT)
8.9 nM10.9 nM
In vitro DMSO 79 mg/mL heating (197.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.04 mL 125.18 mL 250.36 mL
0.5 mM 5.01 mL 25.04 mL 50.07 mL
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A12798
Actions Inhibitor
M. Wt 399.42
Formula C24H18FN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1285515-21-0
Synonyms GSK-2578215A, GSK 2578215A
SMILES C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

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