Catalog No.: A12792

PERK inhibitor


GSK2606414 Chemical Structure

CAS NO. 1337531-36-8

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.

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5 mg
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25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Linhao Xu, .et al. Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation, Neural Plasticity, 2021, 23 Aug
  • Takashi Shimizu, .et al. PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation, Sci Signal, 2021, Jan 26;14(667):eabb3616 PMID: 33500333

Biological Activity

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
EIF2AK3 (PERK) (Cell-free assay) EIF2AK1 (HRI) (Cell-free assay) EIF2AK2 (PKR) (Cell-free assay)
0.4 nM420 nM696 nM
In vitro (25°C) DMSO 87 mg/mL (192.71 mM)
Water Insoluble
Ethanol 18 mg/mL (39.87 mM)
In vivo 5% DMSO+45% PEG 300+ddH2O 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.76 mL 221.51 mL
0.5 mM 4.43 mL 22.15 mL 44.3 mL
1 mM 2.22 mL 11.08 mL 22.15 mL
5 mM 0.44 mL 2.22 mL 4.43 mL

*The above data is based on the productmolecular weight 451.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12792
Actions Inhibitor
CAS No. 1337531-36-8
Formula C24H20F3N5O
M. Wt 451.44
Purity >98%
Synonyms GSK-2606414, GSK 2606414

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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