GSK2606414

Catalog No.: A12792

PERK inhibitor

GSK2606414 Chemical Structure

CAS NO. 1337531-36-8

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.

Availability: In stock

Package Price Qty
5 mg
$85.00
10 mg
$115.00
25 mg
$225.00
50 mg
$335.00
10mM * 1mL in DMSO
$149.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
Targets
EIF2AK3 (PERK) (Cell-free assay) EIF2AK1 (HRI) (Cell-free assay) EIF2AK2 (PKR) (Cell-free assay)
0.4 nM420 nM696 nM
In vitro DMSO 90 mg/mL (199.36 mM)
Water <1 mg/mL (<1 mM)
Ethanol 19 mg/mL (42.08 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.76 mL 221.51 mL
0.5 mM 4.43 mL 22.15 mL 44.3 mL
1 mM 2.22 mL 11.08 mL 22.15 mL
5 mM 0.44 mL 2.22 mL 4.43 mL

*The above data is based on the productmolecular weight 451.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12792
Actions Inhibitor
M. Wt 451.44
Formula C24H20F3N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1337531-36-8
Synonyms GSK-2606414, GSK 2606414
SMILES CN1C=C(C2=C1N=CN=C2N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F

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