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GSK2606414

GSK2606414

Name: GSK2606414
Brand: Adooq Bioscience
SKU: A12792
Rating: 100 (2 reviews)

Catalog No.: A12792

PERK inhibitor

Product Citations (2)

GSK2606414 Chemical Structure

CAS NO. 1337531-36-8

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.

Availability: In stock

Package	Price	Qty
5 mg	$85.00
10 mg	$115.00
25 mg	$225.00
50 mg	$335.00
10mM * 1mL in DMSO	$149.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq GSK2606414

Linhao Xu, .et al. Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation, Neural Plasticity, 2021, 23 Aug
Takashi Shimizu, .et al. PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation, Sci Signal, 2021, Jan 26;14(667):eabb3616 PMID: 33500333

Biological Activity

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.

Targets

EIF2AK3 (PERK) (Cell-free assay)	EIF2AK1 (HRI) (Cell-free assay)	EIF2AK2 (PKR) (Cell-free assay)
0.4 nM	420 nM	696 nM

Solubility *

In vitro (25°C)	DMSO	87 mg/mL (192.71 mM)
	Water	Insoluble
	Ethanol	18 mg/mL (39.87 mM)
In vivo	5% DMSO+45% PEG 300+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.15 mL	110.76 mL	221.51 mL
0.5 mM	4.43 mL	22.15 mL	44.3 mL
1 mM	2.22 mL	11.08 mL	22.15 mL
5 mM	0.44 mL	2.22 mL	4.43 mL

*The above data is based on the productmolecular weight 451.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12792
Actions	Inhibitor
CAS No.	1337531-36-8
Formula	C24H20F3N5O
M. Wt	451.44
Purity	>98%
Synonyms	GSK-2606414, GSK 2606414
SMILES	CN1C=C(C2=C1N=CN=C2N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.