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GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
Targets
| EIF2AK3 (PERK) (Cell-free assay) | EIF2AK1 (HRI) (Cell-free assay) | EIF2AK2 (PKR) (Cell-free assay) | ||
| 0.4 nM | 420 nM | 696 nM |
| In vitro | DMSO | 90 mg/mL (199.36 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 19 mg/mL (42.08 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.15 mL | 110.76 mL | 221.51 mL |
| 0.5 mM | 4.43 mL | 22.15 mL | 44.3 mL |
| 1 mM | 2.22 mL | 11.08 mL | 22.15 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
*The above data is based on the productmolecular weight 451.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A12792 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 451.44 |
| Formula | C24H20F3N5O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1337531-36-8 |
| Synonyms | GSK-2606414, GSK 2606414 |
| SMILES | CN1C=C(C2=C1N=CN=C2N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F |
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