GSK3335103

Catalog No.: A57530
αvβ6 Integrin Inhibitor
GSK3335103 is an orally active, non-peptide inhibitor of the αvβ6 integrin, demonstrating a potent affinity with a pIC50 value of 8. This compound is primarily utilized in research focused on pulmonary fibrosis, aiding in the understanding of its pathophysiology and potential therapeutic interventions. The inhibition of αvβ6 integrin by GSK3335103 can provide insights into cellular mechanisms involved in fibrotic processes.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGSK3335103 is an orally active, non-peptide inhibitor of the αvβ6 integrin, demonstrating a potent affinity with a pIC50 value of 8. This compound is primarily utilized in research focused on pulmonary fibrosis, aiding in the understanding of its pathophysiology and potential therapeutic interventions. The inhibition of αvβ6 integrin by GSK3335103 can provide insights into cellular mechanisms involved in fibrotic processes.
Product Information
Catalog NumA57530
FormulaC27H36FN3O4
Molecular Weight485.59
CAS Number1893340-21-0
SMILESO=C(O)C[C@@H](C1=CC=CC(OCCOC)=C1)CN2C[C@@](CCC3=NC4=C(CCCN4)C=C3)(F)CC2
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