GSK360A is a potent and orally bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PHD) with IC50 values of 10 nM, 100 nM, and 126 nM for PHD1, PHD2, and PHD3, respectively. This compound effectively activates the HIF-1 alpha signaling pathway, providing protective effects on the heart in the context of myocardial infarction (MI). GSK360A holds potential for advancing therapeutic strategies in cardiovascular research and conditions related to oxygen deprivation.
GSK360A is a potent and orally bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PHD) with IC50 values of 10 nM, 100 nM, and 126 nM for PHD1, PHD2, and PHD3, respectively. This compound effectively activates the HIF-1 alpha signaling pathway, providing protective effects on the heart in the context of myocardial infarction (MI). GSK360A holds potential for advancing therapeutic strategies in cardiovascular research and conditions related to oxygen deprivation.
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