Fig. 1 · Structure
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Guanfacine-d2 hydrochloride
Stable Isotope
Guanfacine-d2 hydrochloride is a deuterated form of guanfacine hydrochloride, which primarily targets the α2A-adrenoceptor. This selective agonist exhibits a Kd of 31 nM, demonstrating significant selectivity with a 60-fold preference for the α2A subtype over the α2B receptor. This stable isotope-labeled compound is valuable for pharmacological studies and tracing applications in research related to hypertension and neuropharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1398065-88-7 |
| Applications | Stable Isotope |
| Formula | C9H8D2Cl3N3O |
| Molecular Weight | 284.57 |
| SMILES | N=C(N)NC(C([2H])([2H])C1=C(C=CC=C1Cl)Cl)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.