Guangxitoxin 1E selectively targets and inhibits KV2.1 and KV2.2 channels with an IC50 of 1-3 nM, making it a potent blocker of these potassium channels. These channels are involved in the generation of delayed-rectifier potassium currents in various neuronal types. Guangxitoxin 1E is primarily used in research applications focused on elucidating the physiological roles of KV2 channels and assessing their contributions to neuronal excitability and signaling pathways.
Guangxitoxin 1E selectively targets and inhibits KV2.1 and KV2.2 channels with an IC50 of 1-3 nM, making it a potent blocker of these potassium channels. These channels are involved in the generation of delayed-rectifier potassium currents in various neuronal types. Guangxitoxin 1E is primarily used in research applications focused on elucidating the physiological roles of KV2 channels and assessing their contributions to neuronal excitability and signaling pathways.
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