Guvacine, a GABA uptake inhibitor derived from the nut of Areca catechu, selectively targets GABA transporters. It demonstrates potent inhibition of rat GAT-1, GAT-2, and GAT-3, with IC50 values of 39 μM, 58 μM, and 378 μM, respectively. This compound is instrumental in studies investigating GABAergic signaling and its implications in neurological research. Guvacine's properties make it a valuable tool for exploring therapeutic approaches for disorders linked to altered GABA uptake.
Guvacine, a GABA uptake inhibitor derived from the nut of Areca catechu, selectively targets GABA transporters. It demonstrates potent inhibition of rat GAT-1, GAT-2, and GAT-3, with IC50 values of 39 μM, 58 μM, and 378 μM, respectively. This compound is instrumental in studies investigating GABAergic signaling and its implications in neurological research. Guvacine's properties make it a valuable tool for exploring therapeutic approaches for disorders linked to altered GABA uptake.
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