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GW 9662 is a selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively).
Targets
| PPARγ (Cell-free assay) | PPARα (Cell-free assay) | PPARδ (Cell-free assay) | ||
| 3.3 nM | 32 nM | 2 μM |
| In vitro (25°C) | DMSO | 55 mg/mL (198.78 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.14 mL | 180.71 mL | 361.43 mL |
| 0.5 mM | 7.23 mL | 36.14 mL | 72.29 mL |
| 1 mM | 3.61 mL | 18.07 mL | 36.14 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.23 mL |
*The above data is based on the productmolecular weight 276.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A11984 |
|---|---|
| Actions | Antagonist |
| M. Wt | 276.68 |
| Formula | C13H9N2O3Cl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 22978-25-2 |
| Synonyms | GW9662, GW-9662 |
| SMILES | C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl |
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