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GW3965 HCl

Catalog No.: A11204

LXR-like receptors agonist

GW3965 HCl

GW3965 HCl Chemical Structure

CAS NO. 405911-17-3

GW3965 HCl is a selective and orally active liver X receptor (LXR) full agonist.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Mohácsik P, .et al. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action, Endocrinology, 2018, Feb 1;159(2):1159-1171 PMID: 29253128
  • Pencheva N, .et al. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation., Cell., 2014, 156(5):986-1001 PMID: 24581497
  • Bin Dong, .et al. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway, J Lipid Res., 2013, May; 54(5): 1241-1254. PMID: 23427282

Biological Activity

GW3965 HCl is a selective and orally active liver X receptor (LXR) full agonist.
hLXRβ (Cell-free assay) LXRα/SRC1?LiSA (Cell-free assay) hLXRα (Cell-free assay)
30 nM(EC50)125 nM(EC50)190 nM(EC50)
In vitro DMSO Warmed: 16 mg/mL (25.86 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.17 mL 80.84 mL 161.68 mL
0.5 mM 3.23 mL 16.17 mL 32.34 mL
1 mM 1.62 mL 8.08 mL 16.17 mL
5 mM 0.32 mL 1.62 mL 3.23 mL

*The above data is based on the productmolecular weight 618.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11204
Actions Agonist
CAS No. 405911-17-3
Formula C33H31ClF3NO3.HCl
M. Wt 618.51
Purity >98%
Synonyms GW-3965

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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