GW405833 hydrochloride is a selective agonist of the cannabinoid receptor 2 (CB2) with potent activity, characterized by EC50 and Ki values of 0.65 nM and 3.92 nM, respectively. In addition to its action as a CB2 agonist, GW405833 also acts as a non-competitive antagonist at the CB1 receptor, influencing analgesic pathways. This compound has been shown to significantly inhibit cAMP production stimulated by Forskolin and to down-regulate HIF-1α, which contributes to its potential role in alleviating acute liver failure. GW405833 hydrochloride is valuable for research related to pain management and metabolic disorders.
GW405833 hydrochloride is a selective agonist of the cannabinoid receptor 2 (CB2) with potent activity, characterized by EC50 and Ki values of 0.65 nM and 3.92 nM, respectively. In addition to its action as a CB2 agonist, GW405833 also acts as a non-competitive antagonist at the CB1 receptor, influencing analgesic pathways. This compound has been shown to significantly inhibit cAMP production stimulated by Forskolin and to down-regulate HIF-1α, which contributes to its potential role in alleviating acute liver failure. GW405833 hydrochloride is valuable for research related to pain management and metabolic disorders.
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