H 89 2HCl

Catalog No.: A11935

PKA inhibitor

H 89 2HCl

H 89 2HCl Chemical Structure

CAS NO. 127243-85-0, 130964-39-5

H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase.

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10 mg

Regular Price: $50.00

Special Price $40.00

25 mg

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50 mg

Regular Price: $160.00

Special Price $128.00

100 mg

Regular Price: $280.00

Special Price $224.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Guo Q, .et al. Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells, Biomed Pharmacother, 2020, Mar;123:109812 PMID: 31945696
  • Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924

Biological Activity

H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase.
In vitro (25°C) DMSO 96 mg/mL (184.86 mM)
Water 6 mg/mL (11.55 mM)
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.26 mL 96.28 mL 192.57 mL
0.5 mM 3.85 mL 19.26 mL 38.51 mL
1 mM 1.93 mL 9.63 mL 19.26 mL
5 mM 0.39 mL 1.93 mL 3.85 mL

*The above data is based on the productmolecular weight 519.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11935
Actions Inhibitor
CAS No. 127243-85-0, 130964-39-5
Formula C20H20BrN3O2S.2HCl
M. Wt 519.3
Purity >98%
Synonyms H89 2HCl
SMILES C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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