HBI-2375 is a selective inhibitor of the MLL1-WDR5 interaction, exhibiting a strong binding affinity with an IC50 of 4.48 nM. This compound effectively inhibits proliferation in MV4;11 leukemia cells, with an IC50 of 3.17 µM. Additionally, HBI-2375 disrupts histone methyltransferase activity, making it a valuable tool for research on leukemia, glioma, and glioblastoma. Its ability to penetrate the blood-brain barrier and its oral bioavailability further enhance its potential for in vivo studies.
HBI-2375 is a selective inhibitor of the MLL1-WDR5 interaction, exhibiting a strong binding affinity with an IC50 of 4.48 nM. This compound effectively inhibits proliferation in MV4;11 leukemia cells, with an IC50 of 3.17 µM. Additionally, HBI-2375 disrupts histone methyltransferase activity, making it a valuable tool for research on leukemia, glioma, and glioblastoma. Its ability to penetrate the blood-brain barrier and its oral bioavailability further enhance its potential for in vivo studies.
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