HIF-PHD-IN-1 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), demonstrating an IC50 of 54 nM specifically for human HIF-PHD2. This compound exhibits significant biological activity by stabilizing hypoxia-inducible factors, thereby enhancing erythropoiesis. HIF-PHD-IN-1 holds potential for research applications in renal anemia therapy and related studies exploring oxygen-sensing pathways.
HIF-PHD-IN-1 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), demonstrating an IC50 of 54 nM specifically for human HIF-PHD2. This compound exhibits significant biological activity by stabilizing hypoxia-inducible factors, thereby enhancing erythropoiesis. HIF-PHD-IN-1 holds potential for research applications in renal anemia therapy and related studies exploring oxygen-sensing pathways.
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