HJM-561 is a selective EGFR PROTAC degrader that effectively targets and degrades EGFR mutations resistant to conventional therapies, such as Osimertinib. It demonstrates potent degradation activity against key triple mutations including Del19/T790M/C797S (DC50: 9.2 nM) and L858R/T790M/C797S (DC50: 5.8 nM). HJM-561's mechanism provides promising potential for anti-tumor applications in the treatment of EGFR-driven malignancies.
HJM-561 is a selective EGFR PROTAC degrader that effectively targets and degrades EGFR mutations resistant to conventional therapies, such as Osimertinib. It demonstrates potent degradation activity against key triple mutations including Del19/T790M/C797S (DC50: 9.2 nM) and L858R/T790M/C797S (DC50: 5.8 nM). HJM-561's mechanism provides promising potential for anti-tumor applications in the treatment of EGFR-driven malignancies.
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