Huwentoxin-IV is a selective sodium channel blocker that primarily targets and inhibits neuronal isoforms Nav1.7, Nav1.2, Nav1.3, and Nav1.4, with IC50 values of 26, 150, 338, and 400 nM, respectively. This compound preferentially binds to neurotoxin receptor site 4 on the peripheral nerve subtype Nav1.7, making it an effective candidate for pain management. Huwentoxin-IV exhibits significant analgesic effects in animal models of both inflammatory and neuropathic pain, highlighting its potential utility in pain research and therapeutic applications.
Huwentoxin-IV is a selective sodium channel blocker that primarily targets and inhibits neuronal isoforms Nav1.7, Nav1.2, Nav1.3, and Nav1.4, with IC50 values of 26, 150, 338, and 400 nM, respectively. This compound preferentially binds to neurotoxin receptor site 4 on the peripheral nerve subtype Nav1.7, making it an effective candidate for pain management. Huwentoxin-IV exhibits significant analgesic effects in animal models of both inflammatory and neuropathic pain, highlighting its potential utility in pain research and therapeutic applications.
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