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HX531

Catalog No.: A30050
RXR Antagonist
HX531 is an orally active antagonist of the retinoid X receptor (RXR), demonstrating an IC50 of 18 nM. This compound effectively upregulates the p53-p21Cip1 pathway while counteracting the anti-apoptotic effects of trans-retinoic acid (t-RA). HX531 is characterized by its potential applications in anti-obesity, anti-diabetic, and anti-melanoma research, making it a valuable tool for investigating metabolic and cancer-related pathways.
HX531 188844-34-0 RXR Antagonist
Grouped product items
Size Price Stock Qty
1mg
$40.00
In stock
5mg
$70.00
In stock
10mg
$125.00
In stock
25mg
$275.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHX531 is an orally active antagonist of the retinoid X receptor (RXR), demonstrating an IC50 of 18 nM. This compound effectively upregulates the p53-p21Cip1 pathway while counteracting the anti-apoptotic effects of trans-retinoic acid (t-RA). HX531 is characterized by its potential applications in anti-obesity, anti-diabetic, and anti-melanoma research, making it a valuable tool for investigating metabolic and cancer-related pathways.
Product Information
Catalog NumA30050
FormulaC29H29N3O4
Molecular Weight483.56
CAS Number188844-34-0
SMILESO=C(O)C1=CC=C(C2=NC3=CC([N+]([O-])=O)=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Metabolism > Retinoid Receptor