ICA-105574 is a potent hERG channel activator that primarily functions by inhibiting the inactivation of hERG channels. It significantly increases current amplitudes by more than 10-fold, demonstrating an EC50 of 0.5 ± 0.1 μM and a Hill slope of 3.3 ± 0.2. This compound has been shown to prevent arrhythmias resulting from cardiac delayed repolarization and can concentration-dependently shorten action potential duration in ventricular myocytes, making it valuable for cardiovascular research applications.
ICA-105574 is a potent hERG channel activator that primarily functions by inhibiting the inactivation of hERG channels. It significantly increases current amplitudes by more than 10-fold, demonstrating an EC50 of 0.5 ± 0.1 μM and a Hill slope of 3.3 ± 0.2. This compound has been shown to prevent arrhythmias resulting from cardiac delayed repolarization and can concentration-dependently shorten action potential duration in ventricular myocytes, making it valuable for cardiovascular research applications.
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