Icotinib-d4 is a stable isotope-labeled version of Icotinib, functioning as a highly selective inhibitor of the epidermal growth factor receptor (EGFR), with an IC50 value of 5 nM. This compound effectively inhibits both wild-type and mutant forms of EGFR, including EGFR L858R, EGFR L858R/T790M, EGFRT790M, and EGFR L861Q. Additionally, Icotinib-d4 serves as a click chemistry reagent, featuring an alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a valuable tool for various biochemical applications.
Icotinib-d4 is a stable isotope-labeled version of Icotinib, functioning as a highly selective inhibitor of the epidermal growth factor receptor (EGFR), with an IC50 value of 5 nM. This compound effectively inhibits both wild-type and mutant forms of EGFR, including EGFR L858R, EGFR L858R/T790M, EGFRT790M, and EGFR L861Q. Additionally, Icotinib-d4 serves as a click chemistry reagent, featuring an alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a valuable tool for various biochemical applications.
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