IDO1-IN-25 is a dual inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2), exhibiting IC50 values of 0.17 μM and 3.2 μM, respectively. This compound demonstrates the ability to effectively inhibit nitric oxide production in LPS-stimulated RAW264.7 cells, highlighting its anti-inflammatory potential. Additionally, IDO1-IN-25 has been shown to reduce inflammation in a mouse ear edema model induced by croton oil, making it a valuable tool for studying inflammatory pathways and immune responses.
IDO1-IN-25 is a dual inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2), exhibiting IC50 values of 0.17 μM and 3.2 μM, respectively. This compound demonstrates the ability to effectively inhibit nitric oxide production in LPS-stimulated RAW264.7 cells, highlighting its anti-inflammatory potential. Additionally, IDO1-IN-25 has been shown to reduce inflammation in a mouse ear edema model induced by croton oil, making it a valuable tool for studying inflammatory pathways and immune responses.
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