IDO1/TDO-IN-4 is a dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), exhibiting IC50 values of 3.53 μM and 1.15 μM, respectively. It interacts with IDO1 through hydrogen bonding and engages TDO via π−π stacking interactions. This compound is valuable for investigating the role of IDO1/TDO in depression and related conditions, including infectious, metabolic, and autoimmune disorders.
IDO1/TDO-IN-4 is a dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), exhibiting IC50 values of 3.53 μM and 1.15 μM, respectively. It interacts with IDO1 through hydrogen bonding and engages TDO via π−π stacking interactions. This compound is valuable for investigating the role of IDO1/TDO in depression and related conditions, including infectious, metabolic, and autoimmune disorders.
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