iE-DAP is a potent NOD1 agonist that activates the NOD1 receptor, leading to the stimulation of the NF-κB and MLCK signaling pathways. This results in enhanced cellular inflammatory responses and disruption of tight junction integrity, as evidenced by the downregulation of ZO-1 and Occludin gene expression. In term human trophoblast cell cultures, iE-DAP promotes the secretion of pro-inflammatory cytokines such as IL-6, GRO-α, MCP-1, IL-8, and MIP-1β. It is particularly relevant for research focused on mastitis and preterm birth, as it has been shown to induce fetal inflammation and impact fetal body weight in pregnant murine models.
iE-DAP is a potent NOD1 agonist that activates the NOD1 receptor, leading to the stimulation of the NF-κB and MLCK signaling pathways. This results in enhanced cellular inflammatory responses and disruption of tight junction integrity, as evidenced by the downregulation of ZO-1 and Occludin gene expression. In term human trophoblast cell cultures, iE-DAP promotes the secretion of pro-inflammatory cytokines such as IL-6, GRO-α, MCP-1, IL-8, and MIP-1β. It is particularly relevant for research focused on mastitis and preterm birth, as it has been shown to induce fetal inflammation and impact fetal body weight in pregnant murine models.
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