IGF-1R inhibitor-3

Catalog No.: A34717
IGF1R Inhibitor
IGF-1R inhibitor-3 is an allosteric inhibitor targeting insulin-like growth factor receptor 1 (IGF-1R) kinase, demonstrating an IC50 of 0.2 μM. This compound is instrumental in investigating IGF-1R signaling pathways and its role in various cancers and metabolic disorders. It has potential applications in cancer research, where modulation of the IGF-1R pathway may influence tumor growth and progression.
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionIGF-1R inhibitor-3 is an allosteric inhibitor targeting insulin-like growth factor receptor 1 (IGF-1R) kinase, demonstrating an IC50 of 0.2 μM. This compound is instrumental in investigating IGF-1R signaling pathways and its role in various cancers and metabolic disorders. It has potential applications in cancer research, where modulation of the IGF-1R pathway may influence tumor growth and progression.
Product Information
Catalog NumA34717
FormulaC28H27FN6O
Molecular Weight482.55
CAS Number1227753-12-9
SMILESO=C(C1=CC(F)=CC2=C1NC=C2C#N)NC3CCN(CCCCC4=CNC5=C4C=C(C#N)C=C5)CC3
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