Arginase

BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

CB-1158, also known as INCB01158, is a potent and orally active arginase inhibitor with IC50=89 nM

CB-1158, also known as INCB01158, is a potent and orally active arginase inhibitor with IC50=89 nM) .

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.

nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia.

L-Norvaline is an arginase inhibitor that enhances nitric oxide production and reduces oxidative stress. It has been shown to improve insulin resistance and demonstrates antioxidant and anti-hyperglycemic properties. This compound is particularly relevant in research related to Alzheimer's disease and other metabolic disorders.

Nor-NOHA dihydrochloride is a selective and reversible inhibitor of arginase, particularly impacting the activity of ARG2 under hypoxic conditions. This compound has been shown to induce apoptosis in ARG2-expressing cells and demonstrates anti-leukemic properties. Nor-NOHA dihydrochloride is useful for research applications related to endothelial dysfunction, immunosuppression, and metabolic studies.

Nor-NOHA is a selective and reversible inhibitor of arginase, primarily targeting the regulation of arginine metabolism. It has been shown to induce apoptosis in cells expressing arginase 2 under hypoxic conditions and exhibits anti-leukemic activity. This compound is valuable for research applications related to endothelial dysfunction, immunosuppression, and metabolic studies.

nor-NOHA monoacetate is a selective and reversible inhibitor of arginase. It induces apoptosis in cells expressing arginase 2 under hypoxic conditions and demonstrates anti-leukemic activity. This compound is valuable for investigating endothelial dysfunction, immunosuppression, and metabolic processes in various biological contexts.

ABH hydrochloride is a potent arginase inhibitor with a Ki value of 8.5 nM. This compound enhances nitric oxide production and downregulates inflammatory mediators, including ICAM-1, VCAM-1, and MCP-1. ABH hydrochloride is utilized in research focused on erectile dysfunction, lung protection, wound healing, blood pressure regulation, and vascular fibrosis. Its dual role in promoting vasodilation and reducing inflammation makes it a valuable reagent for studying cardiovascular and inflammatory diseases.

OATD-02 is a competitive, reversible, noncovalent inhibitor that targets arginase 1 and 2. It exhibits slow offset kinetics with IC50 values of 20 nM for human arginase 1, 39 nM for human arginase 2, 39 nM for mouse arginase 1, and 28 nM for rat arginase 1. OATD-02 effectively disrupts tumor immunosuppression mediated by arginases, making it a valuable tool for research in melanoma and other cancer immunotherapy studies.

ARG1-IN-1 is a potent arginase inhibitor with an IC50 value of 29 nM. This compound effectively inhibits serum arginase activity, leading to increased levels of arginine in various mouse tumor models. ARG1-IN-1 is particularly useful for research applications focused on tumor biology and arginine metabolism in cancer.

NED-3238 is a potent inhibitor of arginase I and II, exhibiting IC50 values of 1.3 nM and 8.1 nM, respectively. This compound is valuable in research focused on metabolic regulation and immune modulation, facilitating studies related to cancer, cardiovascular diseases, and inflammation. Its high specificity and potency make it a suitable tool for investigating arginine metabolism and its implications in various biological processes.

(-)-3-O-Acetylcatechin is an arginase inhibitor that demonstrates significant activity against Leishmania amazonensis, with an IC50 value of 3.7 μM. This compound serves as a valuable tool for investigating leishmaniasis and studying arginase-related metabolic pathways in parasitic infections. Its application in biochemical research may contribute to the development of therapeutic strategies for managing leishmaniasis.

BEC is a competitive inhibitor of the binuclear manganese metalloenzyme arginase, functioning as an arginine analogue with slow-binding characteristics. This compound promotes the increased availability of arginine for nitric oxide synthase, thereby facilitating nitric oxide-dependent smooth muscle relaxation in the corpus cavernosum. As a result, BEC is significant in studies related to penile erection and vascular health.

NG-Hydroxy-L-arginine acetate is a selective arginase inhibitor that participates in modulating the nitric oxide pathway. By interfering with the conversion of arginine to citrulline, it facilitates increased nitric oxide production via nitric oxide synthase. This compound is valuable in research related to cardiovascular health, neurobiology, and inflammation, where nitric oxide signaling plays a critical role.

Arginase, Microorganism (immobilized) is an enzyme that plays a crucial role in the urea cycle, catalyzing the hydrolysis of L-arginine to produce L-ornithine and urea. This enzyme is utilized in various biochemical applications, including studies of nitrogen metabolism and modulation of nitric oxide production. Its immobilized form enhances stability and facilitates its use in industrial processes and research settings.