IMP-1088 is a highly potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, exhibiting IC50 values of less than 1 nM for both isoforms and a Kd of under 210 pM for NMT1. This compound effectively inhibits rhinovirus replication by blocking the N-myristoylation of the virus-encoded protein VP0, thereby preventing the virus from completing its lifecycle. In addition, IMP-1088 offers protective effects to host cells by mitigating the cytotoxic consequences associated with viral infections, making it a valuable tool for research into antiviral therapies.
IMP-1088 is a highly potent dual inhibitor of human N-myristoyltransferases NMT1 and NMT2, exhibiting IC50 values of less than 1 nM for both isoforms and a Kd of under 210 pM for NMT1. This compound effectively inhibits rhinovirus replication by blocking the N-myristoylation of the virus-encoded protein VP0, thereby preventing the virus from completing its lifecycle. In addition, IMP-1088 offers protective effects to host cells by mitigating the cytotoxic consequences associated with viral infections, making it a valuable tool for research into antiviral therapies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
