Fig. 1 · Structure
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INCB086550
PD-L1 Inhibitor
INCB086550 is a potent oral small-molecule inhibitor of PD-L1, exhibiting IC50 values of 3.1, 4.9, and 1.9 nM for human, cynomolgus, and rat PD-L1, respectively. This compound promotes the dimerization of cell-surface PD-L1 and facilitates its entry into Golgi vesicles, leading to nuclear trafficking. INCB086550 is primarily used in cancer research, particularly in studies focusing on immune checkpoint regulation and tumor microenvironment modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2230911-59-6 |
| Applications | PD-L1 Inhibitor |
| Formula | C41H39N7O4 |
| Molecular Weight | 693.79 |
| Synonyms | PD-1/PD-L1-IN-8 |
| SMILES | N#CC1=C2C(N=C(C3=C(C(C4=C(C(NC5=NC=CC6=C5N=CC(CN7CC[C@H](C7)O)=C6)=CC=C4)C)=CC=C3)C)O2)=CC(CN8C[C@@H](CC8)C(O)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.