Indantadol is a non-selective NMDA receptor antagonist and MAO inhibitor, demonstrating a non-competitive blockade of [³H]-MK-801 binding with an IC50 of 8.1 μM. It effectively inhibits NMDA-induced dopamine release and exhibits neuroprotective effects, with an ED₅₀ value of 35 μM. Additionally, Indantadol displays significant anticonvulsant properties and mitigates high pain hypersensitivity, making it a valuable reagent for research in neuropharmacology and pain modulation.
Indantadol is a non-selective NMDA receptor antagonist and MAO inhibitor, demonstrating a non-competitive blockade of [³H]-MK-801 binding with an IC50 of 8.1 μM. It effectively inhibits NMDA-induced dopamine release and exhibits neuroprotective effects, with an ED₅₀ value of 35 μM. Additionally, Indantadol displays significant anticonvulsant properties and mitigates high pain hypersensitivity, making it a valuable reagent for research in neuropharmacology and pain modulation.
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