Inotersen sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide that targets the transthyretin (TTR) RNA transcript to inhibit the production of TTR protein. This reduction in TTR levels makes Inotersen sodium a valuable tool for studying hereditary TTR amyloidosis polyneuropathy. Its mechanism of action provides insight into potential therapeutic strategies for related disorders.
Inotersen sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide that targets the transthyretin (TTR) RNA transcript to inhibit the production of TTR protein. This reduction in TTR levels makes Inotersen sodium a valuable tool for studying hereditary TTR amyloidosis polyneuropathy. Its mechanism of action provides insight into potential therapeutic strategies for related disorders.
Product Information
Catalog Num
A79387
Molecular Weight
7183.08 (free acid)
CAS Number
1432726-13-0
Sequence
DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'- O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]rG-G-T-T-A-m5C-A-T-G-A-A-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC) nonadeca sodium salt
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