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Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of topoisomerase 1 involved in cellular DNA replication and transcription.
Targets
| Topo I | ||||
| In vitro (25°C) | DMSO | 100 mg/mL (147.67 mM) | |
| Water | 1 mg/mL (1.47 mM) | ||
| Ethanol | 7 mg/mL (10.33 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.77 mL | 73.83 mL | 147.67 mL |
| 0.5 mM | 2.95 mL | 14.77 mL | 29.53 mL |
| 1 mM | 1.48 mL | 7.38 mL | 14.77 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.95 mL |
*The above data is based on the productmolecular weight 677.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10479 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 677.2 |
| Formula | C33H38N4O6.HCl.3H2O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 136572-09-3 |
| Synonyms | CPT 11, Camptosar, Campto, Irinotecan |
| SMILES | CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[[email protected]@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7.O.O.O.Cl |
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