Isotope-Labeled Compounds

Squalene-d6 is a deuterium-labeled form of squalene, a key intermediate in cholesterol biosynthesis. This stable isotope is utilized in tracer studies to explore metabolic pathways and pharmacological properties, including hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumor activities. Its applications span diverse fields such as lipid metabolism research, cardiovascular studies, and cancer biology.

L-Lysine-13C6,15N2 dihydrochloride is a stable isotope-labeled form of L-Lysine, incorporating both 15N and 13C isotopes. This reagent is utilized in metabolic studies and tracer experiments, allowing researchers to track the incorporation and metabolism of lysine in various biological systems. Its isotopic labeling provides valuable insights into nitrogen and carbon metabolism, making it a vital tool for studies in biochemistry, pharmacology, and physiological research.

Picolinic acid-d4 is a stable isotope-labeled form of picolinic acid, characterized by the substitution of four hydrogen atoms with deuterium. This compound is primarily utilized as an internal standard in mass spectrometry and other analytical techniques, aiding in the quantification of metabolites and tracing pathways involving picolinic acid. Its unique isotopic signature enhances sensitivity and accuracy in biochemical research applications.

3-Nitrophenylhydrazine-13C6 hydrochloride is a stable isotope-labeled derivative of 3-Nitrophenylhydrazine. This compound serves as a valuable tool in isotope tracing studies, enabling the investigation of metabolic pathways and chemical reactions in biological systems. Its utility extends to applications in analytical chemistry and organic synthesis, where precise quantification and tracking of isotopically labeled substrates are required.

HEPES-d18 is a deuterium-labeled derivative of HEPES, a zwitterionic buffer that is widely utilized in cell culture applications. It maintains a stable pH range of 6.8 to 8.2, making it ideal for various biological experiments. Additionally, HEPES-d18 serves as an effective inducer of lysosome biogenesis, contributing to cellular studies related to autophagy and lysosomal function. This stable isotope variant allows for precise tracking and analysis in research settings.

1,1,3,3-Tetraethoxypropane-d2 is a stable isotope-labeled derivative of 1,1,3,3-Tetraethoxypropane. This compound is utilized in chemical research for tracing and quantification applications, particularly in studying reaction mechanisms and pathways through NMR spectroscopy. Its deuterium labeling enhances the precision of analytical techniques, facilitating accurate investigations in various fields of synthetic organic chemistry.

Cyclic AMP-13C5 is a deuterated form of cyclic adenosine monophosphate (cAMP), a critical signaling molecule involved in various biological processes. Its stable isotope labeling makes it an invaluable tool for metabolic studies, allowing for precise tracking of cAMP dynamics in biological systems. This reagent is particularly useful in elucidating signaling pathways and studying cellular responses to hormones and neurotransmitters.

Ursodeoxycholic acid-d4 is a deuterium-labeled version of ursodeoxycholic acid, serving as a stable isotope for various biochemical studies. This secondary bile acid, produced by the conversion of (cheno)deoxycholic acid by intestinal microbiota, plays a crucial role in maintaining intestinal barrier integrity and is vital for lipid metabolism. It functions as a signaling molecule by interacting with receptors such as the G-protein coupled bile acid receptor 5 (TGR5) and the farnesoid X receptor (FXR). Ursodeoxycholic acid-d4 is applicable in research focused on hepatic and gastrointestinal diseases, and it demonstrates potential in modulating ACE2 expression, thereby contributing to investigations on SARS-CoV-2 infection.

Dodecane-d26 is a deuterium-labeled stable isotope of dodecane, primarily utilized as an internal standard in mass spectrometry and NMR applications. Its unique isotopic signature enhances the accuracy of quantitative analyses in chemical research. Dodecane-d26 is valuable in studies involving hydrocarbon behavior, metabolic pathways, and environmental monitoring, providing reliable data for various scientific investigations.

Xanthine-13C,15N2 is a stable isotope-labeled form of xanthine, incorporating both 15N and 13C isotopes. This compound functions as an intermediate in the purine degradation pathway and exhibits mild stimulant activity on the central nervous system. It is valuable for applications in metabolic studies, tracking pathways of purine metabolism, and investigating xanthine's biological effects in various research settings.

Apatinib-d8 hydrochloride is a deuterated form of Apatinib hydrochloride, designed as a stable isotope for metabolic studies. This reagent allows for the exploration of pharmacokinetics and biotransformation pathways in various biological systems. Its unique labeling makes it suitable for advanced research applications, including drug metabolism and bio-distribution analysis.

N-Nitrosodipropylamine-d14 is a stable isotope-labeled analog of N-Nitrosodipropylamine, featuring deuterium substitutions. This compound is primarily utilized in the study of nitrosamine metabolism and toxicology. Its incorporation in biochemical assays enables precise tracking and quantification, making it valuable for pharmacokinetic and environmental research applications.

DL-Histidine-d3 is a deuterated form of histidine, serving as a stable isotope labeled compound. It is primarily used in metabolic studies and tracer experiments to investigate histidine metabolism and its biological roles. This reagent is valuable for researchers utilizing mass spectrometry techniques and other analytical methods to study metabolic pathways involving histidine and related compounds.

Lyso GB3-d7 is a deuterium-labeled analog of Lyso GB3, designed for studies involving glycosphingolipids. This stable isotope enables precise tracking and quantification in biochemical assays, enhancing research on lysosomal storage disorders and ganglioside metabolism. Its unique labeling allows for detailed mass spectrometry analyses and collaborative investigations into cellular membrane dynamics.

TCEP-d16 hydrochloride is a deuterium-labeled derivative of Tris(2-carboxyethyl)phosphine hydrochloride, a non-thiol reducing agent that effectively reduces disulfide bonds in proteins. This stable compound facilitates rapid reduction reactions while maintaining the integrity of other thiol-directed agents present in the reaction environment. TCEP-d16 hydrochloride is widely utilized in biochemical research, particularly in studies involving protein folding, stability, and interactions, as well as in DNA and gold nanoparticle chemistry.

Betaine-d3 chloride is a deuterium-labeled derivative of Betaine chloride, serving as a stable isotope. It is primarily utilized in metabolic studies and tracer experiments, enabling researchers to investigate metabolic pathways and quantify biochemical reactions involving Betaine. Its unique labeling allows for precise tracking in various biological applications, enhancing the understanding of cellular processes influenced by Betaine.

Potassium 1H-indol-3-yl sulfate-d5 is a deuterium-labeled derivative of 3-Indoxyl Sulfate potassium, serving as a stable isotope for advanced biochemical studies. This compound is a metabolite of tryptophan generated by intestinal microbiota and sulfated in the liver prior to systemic circulation. It exhibits significant biological activity as an endogenous agonist of the aryl hydrocarbon receptor (AhR) and is classified as a urinary toxin. Potassium 1H-indol-3-yl sulfate-d5 is valuable for research focused on kidney diseases and related metabolic pathways.

Antipyrine-d3 is a deuterium-labeled analog of Antipyrine, primarily utilized as a stable isotope. Antipyrine serves as an antipyretic and analgesic and is commonly used as a probe to study oxidative metabolism. This compound plays a crucial role in assessing hepatic oxidative capacity, making it valuable for various pharmacokinetic and toxicological research applications.

Trimethyllysine-d9 is a deuterium-labeled derivative of Trimethyllysine, a key post-translationally modified amino acid. This compound plays a crucial role in carnitine biosynthesis and is involved in various epigenetic processes. Its stable isotope characteristics make it useful for quantitative analysis in metabolic studies and epigenetic research applications.

2-Bromonaphthalene-d7 is a stable isotope-labeled compound, specifically deuterated at the aromatic ring. This reagent serves as a valuable tool in tracing experiments, particularly in studies involving reaction mechanisms and metabolic pathways. Its incorporation into chemical research enables accurate quantitative analysis and enhances the understanding of various biological processes.

(±)-Equol-d4 is a deuterated form of equol, serving as a stable isotope-labeled compound. It is primarily used in metabolic studies and tracer experiments to investigate the metabolism and biological effects of equol in various biological systems. This labeled compound is valuable for researchers studying the role of equol in health and disease, particularly in relation to estrogenic activity and gut microbiota interactions.

16:0-18:1 PE-d31 is a deuterated phosphatidylethanolamine that serves as a stable isotope-labeled analog of 16:0-18:1 PE. This compound is commonly employed in lipid metabolic studies and phospholipid research to investigate membrane dynamics and cellular signaling pathways. Its isotopic labeling facilitates advanced analytical techniques, such as mass spectrometry, providing enhanced sensitivity and specificity in lipidomic profiling.

1-Iodoethane-1,1,2,2,2-d5 is a deuterated stable isotope of 1-Iodoethane, which serves as a valuable tracer in various chemical and biological research applications. This compound is utilized in studies requiring deuterium labeling to enhance sensitivity in mass spectrometry and NMR analyses. Its unique isotopic signature makes it ideal for tracking molecular pathways and interactions in complex biological systems, facilitating advancements in metabolic studies and chemical reaction mechanisms.

Tripentadecanoin-d29 is a deuterium-labeled derivative of Tripentadecanoin, functioning as a stable isotope. This reagent is primarily utilized in metabolic studies and kinetic analyses of lipid metabolism. Its isotopic labeling enables precise tracking and quantification of lipid-derived compounds in biological systems, facilitating research in biochemistry and cellular biology.

Glycolaldehyde-1-13C is a stable isotope-labeled variant of glycolaldehyde, featuring a carbon-13 isotope at the first carbon position. As a vital building block in organic synthesis, it serves as an important tool in metabolic studies and tracer experiments in biochemical research. Its applications include investigating metabolic pathways, cellular metabolism, and chemical reactions involving carbon compounds.

Bromoethanol-d4 is a stable isotope-labeled variant of bromoethanol, featuring deuterium substitution. This compound serves as a valuable tracer in pharmacokinetic studies and metabolic research, aiding in the investigation of biochemical pathways. Its incorporation into experiments facilitates enhanced detection and analysis using mass spectrometry, thus providing clearer insights into the dynamics of biological processes involving bromoethanol.

24(RS)-Hydroxycholesterol-d7 is a deuterium-labeled derivative of 24(RS)-Hydroxycholesterol, primarily used as a stable isotope-labeled internal standard in quantitative analysis. This compound serves as a valuable tool in lipid research, particularly in the study of cholesterol metabolism and transport. It aids in the accurate measurement of cholesterol-related metabolites in biological samples, facilitating insights into various metabolic disorders and conditions.

Dimethylamine-d6 hydrochloride is a stable isotope-labeled compound that serves as a deuterated form of dimethylamine hydrochloride. This reagent is utilized in research to study metabolic pathways and trace the synthesis of dimethylnitrosamine, a known potent carcinogen across various animal species. Its labeling allows for enhanced detection and quantification in analytical applications, facilitating investigations in toxicology and environmental studies.

Phenanthrene-d10 is a deuterium-labeled derivative of phenanthrene, a polycyclic aromatic hydrocarbon (PAH) commonly utilized in environmental studies. As a stable isotope, it serves as a useful internal standard for identifying and quantifying PAHs in contaminated samples. Phenanthrene is known to induce oxidative stress and inflammation, making this compound relevant for research in toxicology and environmental monitoring of PAH exposure effects.

1H-Benzotriazole-4,5,6,7-d4 is a deuterated stable isotope of 1H-Benzotriazole. This compound serves as a valuable internal standard for mass spectrometry and other analytical techniques, aiding in the quantitative analysis of chemical substances. Its use in research applications includes the study of chemical reactions and the detection of trace amounts of benzotriazole derivatives in complex mixtures.

Treprostinil-d9 is a deuterium-labeled form of Treprostinil, specifically designed as a stable isotope. This compound is a potent agonist of the DP1 and EP2 receptors, exhibiting EC50 values of 0.6±0.1 nM and 6.2±1.2 nM, respectively. Its unique labeling allows for enhanced tracking and quantification in various biological studies, making it suitable for pharmacokinetics, metabolism, and mechanism-of-action investigations in research applications.

2-Carboxyphenol-d4 is a deuterium-labeled derivative of 2-Carboxyphenol, a plant hormone that plays a crucial role in mediating host responses to microbial pathogens. This stable isotope is valuable for tracing and quantification in metabolic studies, providing insights into plant defense mechanisms and interactions with pathogens. Researchers can utilize 2-Carboxyphenol-d4 for advanced studies in plant biology, signaling pathways, and environmental adaptations.

Inosine-15N4 is a stable isotope form of Inosine, labeled with nitrogen-15. This compound serves as a valuable tool in biological research, allowing for enhanced tracking of nucleoside metabolism and dynamics in various biochemical pathways. Its applications include studies in nucleotide synthesis, cellular signaling, and metabolic profiling, facilitating in-depth understanding of biological processes involving purine nucleosides.

(S)-Malic acid-13C4 is a stable isotope-labeled form of S-Malic acid. This reagent serves as a valuable tool for metabolic studies, particularly in tracing and quantifying metabolic pathways in biological research. Its stable carbon isotopes enhance the accuracy of metabolic flux analysis and can be utilized in various applications such as NMR spectroscopy and isotopic labeling studies.

DL-3-Phenylalanine-d8 is a stable isotope-labeled form of DL-3-Phenylalanine, featuring eight deuterium atoms. This compound serves as a valuable tool in metabolic studies, enabling the investigation of phenylalanine pathways and dynamics in biological systems through mass spectrometry. Its incorporation in experimental designs can enhance the precision of quantification and tracking of metabolic processes involving amino acids.

Pyridoxamine-d3 dihydrochloride is a deuterium-labeled derivative of Pyridoxamine. This stable isotope is utilized in metabolic studies and tracer experiments to elucidate the biochemical pathways of vitamin B6 in biological systems. Its incorporation into research applications allows for enhanced tracking and quantification of Pyridoxamine metabolism in various cellular contexts.

Squalane-d62 is a deuterium-labeled derivative of squalane, a saturated form of squalene naturally occurring in specific fish oils and certain vegetable oils. This stable isotope is employed primarily in metabolic and pharmacokinetic studies due to its use as a tracer in lipid metabolism research. Squalane exhibits notable biological activities, including antioxidant properties and skin moisturizing effects, making it relevant in both cosmetic and therapeutic research applications.

Uridine-13C5 is a stable isotope-labeled form of uridine, featuring five carbon-13 isotopes. As a nucleoside, it consists of uracil connected to a ribose sugar via a β-N1-glycosyl bond. This compound is primarily utilized in metabolic labeling studies, enabling detailed tracking of nucleic acid synthesis and turnover in various biological systems. Its applications extend to cellular metabolism research and the investigation of RNA dynamics.

Tributyl phosphate-d27 is a deuterated form of Tributyl phosphate, functioning as a stable isotope. It is utilized in various analytical applications, including mass spectrometry, where it serves as an internal standard for quantifying tributyl phosphate and its metabolites. This reagent aids in improving the accuracy of trace analysis in environmental, biological, and chemical research settings.

β-Sitosterol-d7 (Mixture of Diastereomers) is a deuterated form of β-Sitosterol, consisting of a mixture of diastereomers. This stable isotope is essential for studies involving metabolic pathways, isotope tracing, and pharmacokinetic analysis. Its incorporation into research can aid in understanding lipid metabolism and the biological roles of sterols in various physiological processes.

L-Lysine-d4 dihydrochloride is a deuterium-labeled analog of the essential amino acid L-Lysine. This stable isotope is primarily utilized in metabolic studies and tracer applications, allowing for enhanced tracking of amino acid metabolism in various biological systems. Its incorporation into research enables precise quantification of L-Lysine and its derivatives in complex matrices.

(±)-Jasmonic acid-d5 is a deuterated form of (±)-Jasmonic acid, a known plant growth regulator derived from α-linolenic acid. This compound is utilized to investigate the role of jasmonic acid in plant physiology, particularly its effects on chlorophyll degradation in barley leaf segments and inhibition of elongation in rice seedlings. Its stable isotope labeling enables nuanced studies in metabolic and physiological pathways relevant to plant growth and response to stress.

20-HETE-d6 is a deuterium-labeled analog of 20-Hydroxyeicosatetraenoic acid (20-HETE), a bioactive lipid involved in various physiological processes. As a stable isotope, it serves as a valuable internal standard in mass spectrometry applications for quantifying 20-HETE and understanding its metabolic pathways. This reagent is essential for research in vascular biology, cell signaling, and the pathophysiology of several diseases, including hypertension and cancer.

Ethylenediaminetetraacetic acid-d12 is a deuterium-labeled version of Ethylenediaminetetraacetic acid (EDTA), a potent metal chelator targeting divalent and trivalent cations, including calcium. This reagent demonstrates significant anticoagulant properties and anti-hypercalcemic activity. Ethylenediaminetetraacetic acid-d12 is useful in reducing metal ion-catalyzed oxidative damage to proteins and maintaining a reducing environment during protein purification, while also minimizing disulfide bond formation. It is valuable for various research applications in biochemistry and molecular biology.

Ammonium sulfate, ≥99.0%, AR-15N2 is a deuterium-labeled form of ammonium sulfate, an inorganic sulfate salt. It primarily serves as a stable isotope in various biochemical applications. This reagent is essential for molecular biology research, aiding in protein purification and enzyme activity studies. Its high purity ensures reliability in experimental outcomes and analytical techniques.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 is a deuterium-labeled variant of the phospholipid 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), which serves as a critical component in biological membranes. The incorporation of deuterium allows for enhanced tracking and analysis of lipid dynamics in various biological systems. This reagent is valuable for studies involving lipid metabolism, membrane structure, and dynamics, providing insights into cellular processes and signaling pathways.

N-Nitrosomorpholine-d8 is a deuterium-labeled variant of N-Nitrosomorpholine, a nitrosamine compound known for its light sensitivity. This compound has been identified as a potent carcinogen in animal studies, making it significant for research into cancer biology and toxicology. N-Nitrosomorpholine-d8 serves as a valuable tool in examining metabolic pathways and the effects of nitrosamines in biological systems.

DL-Cystine-d6 is a deuterated form of DL-Cystine, functioning as a stable isotope. It serves as an important tool in metabolic studies, allowing for precise tracking of cysteine and its derivatives in biological systems. This reagent is particularly useful in isotopic labeling experiments and mass spectrometry applications, facilitating a deeper understanding of cysteine metabolism and related biochemical pathways.

tert-Butyl piperazine-1-carboxylate-2,2,3,3,5,5,6,6-d8 is a deuterated derivative of tert-Butyl piperazine-1-carboxylate, serving as a stable isotope label. This compound is primarily utilized in various spectroscopic and analytical techniques, aiding in quantitative analysis and metabolic tracing studies in chemical research. Its integration into experimental designs enhances the accuracy of data interpretation, making it suitable for applications in pharmacokinetics and drug metabolism investigations.

TMA chloride-d12 is a deuterium-labeled derivative of tetramethylammonium chloride, serving as a stable isotope. This reagent is valuable in isotopic labeling studies, particularly in chemical and biological research, where it aids in the investigation of metabolic pathways and the elucidation of reaction mechanisms. Its incorporation into various experimental setups enhances the detection and quantification of compounds through techniques such as NMR and mass spectrometry.