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$0.00 - Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
Biological Activity
Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
Targets
| CYP3A4 | ||||
| In vitro (25°C) | DMSO | Warmed: 7 mg/mL (9.91 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+10% Tween 80+45% ddH2O | 1.66 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.17 mL | 70.86 mL | 141.71 mL |
| 0.5 mM | 2.83 mL | 14.17 mL | 28.34 mL |
| 1 mM | 1.42 mL | 7.09 mL | 14.17 mL |
| 5 mM | 0.28 mL | 1.42 mL | 2.83 mL |
*The above data is based on the productmolecular weight 705.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10489 |
|---|---|
| CAS No. | 84625-61-6 |
| Formula | C35H38Cl2N8O4 |
| M. Wt | 705.65 |
| Purity | >98% |
| Synonyms | Sporanox |
| SMILES | CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[[email protected]]5CO[[email protected]](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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