Itraconazole (Sporanox)

Catalog No.: A10489

Itraconazole (Sporanox)

Itraconazole (Sporanox) Chemical Structure

CAS NO. 84625-61-6

Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.

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  • Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682

Biological Activity

Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
Targets
CYP3A4
In vitro (25°C) DMSO Warmed: 7 mg/mL (9.91 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+40% PEG 300+10% Tween 80+45% ddH2O 1.66 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.17 mL 70.86 mL 141.71 mL
0.5 mM 2.83 mL 14.17 mL 28.34 mL
1 mM 1.42 mL 7.09 mL 14.17 mL
5 mM 0.28 mL 1.42 mL 2.83 mL

*The above data is based on the productmolecular weight 705.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10489
CAS No. 84625-61-6
Formula C35H38Cl2N8O4
M. Wt 705.65
Solubility DMSO
Purity >98%
Synonyms Sporanox
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[[email protected]]5CO[[email protected]](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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