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ITZ-1

ERK-MAPK Pathway Inhibitor

ITZ-1 is a selective inhibitor of the extracellular signal-regulated kinase (ERK) in the mitogen-activated protein kinase (MAPK) pathway, exhibiting an IC50 of 0.51 μM against interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. This compound effectively reduces MMP-13 expression and mitigates nitric oxide (NO)-induced chondrocyte apoptosis. ITZ-1 holds potential for advancing research in osteoarticular diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1180532-17-5
Applications	ERK-MAPK Pathway Inhibitor
Formula	C₂₀H₂₀F₅N₃O₃S₃
Molecular Weight	541.58
SMILES	O=S(C1=CC=C(C)C=C1)(/N=C(C2=C(SCCCC(F)(F)C(F)(F)F)SC(C)=C(C)N23)\NC3=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.