IWP-3

Catalog No.: A13192

Wnt inhibitor

IWP-3

IWP-3 Chemical Structure

CAS NO. 687561-60-0

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $98.00

Special Price $78.40

10 mg

Regular Price: $180.00

Special Price $144.00

25 mg

Regular Price: $390.00

Special Price $312.00

100 mg

Regular Price: $1,100.00

Special Price $880.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.64 mL 103.18 mL 206.36 mL
0.5 mM 4.13 mL 20.64 mL 41.27 mL
1 mM 2.06 mL 10.32 mL 20.64 mL
5 mM 0.41 mL 2.06 mL 4.13 mL

*The above data is based on the productmolecular weight 484.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A13192
Actions Inhibitor
M. Wt 484.59
Formula C22H17FN4O2S3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 687561-60-0
Synonyms IWP 3,IWP3
SMILES O=C(CSC(N1C2=CC=C(F)C=C2)=NC3=C(SCC3)C1=O)NC4=NC5=C(C=C(C)C=C5)S4

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy IWP-3 | IWP-3 Supplier | purchase IWP-3 | IWP-3 cost | IWP-3 manufacturer | order IWP-3 | IWP-3 distributor | buy 687561-60-0| 687561-60-0 Supplier | purchase 687561-60-0 | 687561-60-0 cost | 687561-60-0 manufacturer | order 687561-60-0 | 687561-60-0 distributor
Rewards