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IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.64 mL | 103.18 mL | 206.36 mL |
| 0.5 mM | 4.13 mL | 20.64 mL | 41.27 mL |
| 1 mM | 2.06 mL | 10.32 mL | 20.64 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.13 mL |
*The above data is based on the productmolecular weight 484.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A13192 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 484.59 |
| Formula | C22H17FN4O2S3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 687561-60-0 |
| Synonyms | IWP 3,IWP3 |
| SMILES | O=C(CSC(N1C2=CC=C(F)C=C2)=NC3=C(SCC3)C1=O)NC4=NC5=C(C=C(C)C=C5)S4 |
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