Janagliflozin is a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), exhibiting an IC50 of 0.0058 μM for SGLT2 and 4.802 μM for SGLT1. This compound functions primarily in the proximal renal tubules to inhibit glucose reabsorption, thereby enhancing urinary glucose excretion and lowering blood glucose levels. Janagliflozin holds potential for research applications targeting type 2 diabetes mellitus.
Janagliflozin is a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), exhibiting an IC50 of 0.0058 μM for SGLT2 and 4.802 μM for SGLT1. This compound functions primarily in the proximal renal tubules to inhibit glucose reabsorption, thereby enhancing urinary glucose excretion and lowering blood glucose levels. Janagliflozin holds potential for research applications targeting type 2 diabetes mellitus.
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