JBJ-04-125-02 is a potent allosteric inhibitor of the epidermal growth factor receptor (EGFR), demonstrating selective activity against mutant forms, particularly EGFRL858R/T790M, with an IC50 of 0.26 nM. This compound effectively inhibits the proliferation of cancer cells and disrupts signaling pathways associated with EGFRL858R/T790M/C797S mutations. JBJ-04-125-02 exhibits significant anti-tumor properties, making it a valuable tool for research in targeted cancer therapies.
JBJ-04-125-02 is a potent allosteric inhibitor of the epidermal growth factor receptor (EGFR), demonstrating selective activity against mutant forms, particularly EGFRL858R/T790M, with an IC50 of 0.26 nM. This compound effectively inhibits the proliferation of cancer cells and disrupts signaling pathways associated with EGFRL858R/T790M/C797S mutations. JBJ-04-125-02 exhibits significant anti-tumor properties, making it a valuable tool for research in targeted cancer therapies.
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