JMV 449 is a potent neurotensin receptor agonist, demonstrating an IC50 of 0.15 nM for the inhibition of [125I]-neurotensin binding in neonatal mouse brain assays. Additionally, it shows an EC50 of 1.9 nM in inducing contractions in the guinea pig ileum. JMV 449 exhibits significant hypothermic and analgesic effects in murine models, making it a valuable tool for research in pain management and neuropharmacology.
JMV 449 is a potent neurotensin receptor agonist, demonstrating an IC50 of 0.15 nM for the inhibition of [125I]-neurotensin binding in neonatal mouse brain assays. Additionally, it shows an EC50 of 1.9 nM in inducing contractions in the guinea pig ileum. JMV 449 exhibits significant hypothermic and analgesic effects in murine models, making it a valuable tool for research in pain management and neuropharmacology.
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