JNJ-1250132 is a potent oral steroidal antagonist of the progesterone receptor (PR), exhibiting an IC50 of 1.3 nM. Its primary mechanism involves inhibiting the receptor's binding to DNA, making it valuable for studying PR-mediated processes. Additionally, JNJ-1250132 acts as a competitive inhibitor for both the human glucocorticoid receptor (GR) with an IC50 of 0.50 nM and the rat androgen receptor (AR) with an IC50 of 5.6 nM. This compound's selective profile also shows weak inhibition of the human estrogen receptor (ER), providing insights for research on hormone receptor pathways.
JNJ-1250132 is a potent oral steroidal antagonist of the progesterone receptor (PR), exhibiting an IC50 of 1.3 nM. Its primary mechanism involves inhibiting the receptor's binding to DNA, making it valuable for studying PR-mediated processes. Additionally, JNJ-1250132 acts as a competitive inhibitor for both the human glucocorticoid receptor (GR) with an IC50 of 0.50 nM and the rat androgen receptor (AR) with an IC50 of 5.6 nM. This compound's selective profile also shows weak inhibition of the human estrogen receptor (ER), providing insights for research on hormone receptor pathways.
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