JNJ-26076713 is a potent and orally active antagonist of alpha V integrins, showing IC50 values of 2.3 nM for alpha(V)beta(3) and 6.3 nM for alpha(V)beta(5). This compound effectively inhibits retinal neovascularization, making it a valuable tool for research in vascular biology and potential therapeutic applications in ocular diseases. Its specificity for alpha V integrins positions JNJ-26076713 as a significant reagent for studying integrin-mediated processes.
JNJ-26076713 is a potent and orally active antagonist of alpha V integrins, showing IC50 values of 2.3 nM for alpha(V)beta(3) and 6.3 nM for alpha(V)beta(5). This compound effectively inhibits retinal neovascularization, making it a valuable tool for research in vascular biology and potential therapeutic applications in ocular diseases. Its specificity for alpha V integrins positions JNJ-26076713 as a significant reagent for studying integrin-mediated processes.
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