JNJ 26854165

Catalog No.: A10491

p53 activator

JNJ 26854165

JNJ 26854165 Chemical Structure

CAS NO. 881202-45-5

JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$90.00
50 mg
$380.00
100 mg
$560.00
10mM * 1mL in DMSO
$92.00
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  • Chang SJ, .et al. Proteomic investigating the cooperative lethal effect of EGFR and MDM2 inhibitors on ovarian carcinoma, Arch Biochem Biophys, 2018, Jun 1;647:10-32 PMID: 29655550

Biological Activity

JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.
In vitro (25°C) DMSO 66 mg/mL (200.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.08 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.45 mL 152.25 mL 304.51 mL
0.5 mM 6.09 mL 30.45 mL 60.9 mL
1 mM 3.05 mL 15.23 mL 30.45 mL
5 mM 0.61 mL 3.05 mL 6.09 mL

*The above data is based on the productmolecular weight 328.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10491
Actions Activator
M. Wt 328.4
Formula C21H20N4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 881202-45-5
Synonyms JNJ26854165, JNJ-26854165
SMILES C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4

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