Fig. 1 · Structure
Documents & Downloads
JNJ-40413269
Cat. No.
A74665
CAS
1184847-16-2
FAAH Inhibitor
JNJ-40413269 is a potent inhibitor of fatty acid amide hydrolase (FAAH), demonstrating inhibition of human and rat FAAH with IC50 values of 28 nM and 270 nM, respectively. This compound exhibits notable analgesic efficacy in the rat spinal nerve ligation model, making it a valuable tool for pain research. Additionally, JNJ-40413269 showcases favorable pharmacokinetic properties in rats, supporting its potential utility in pharmaceutical development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1184847-16-2 |
| Applications | FAAH Inhibitor |
| Formula | C19H15ClF3N3O |
| Molecular Weight | 393.79 |
| SMILES | FC(F)(F)C1=CC=C(C2=NC=NC(NC[C@H](O)C3=CC=CC=C3)=C2)C=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.