JNJ-54082730 is a potent phosphodiesterase (PDE) inhibitor targeting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM, and 87.1 nM, respectively. It enhances AMPA receptor activity, modulating synaptic plasticity and improving learning and memory functions in rodent models. Furthermore, JNJ-54082730 exhibits the ability to cross the blood-brain barrier, making it a valuable tool for neuropharmacological research.
JNJ-54082730 is a potent phosphodiesterase (PDE) inhibitor targeting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM, and 87.1 nM, respectively. It enhances AMPA receptor activity, modulating synaptic plasticity and improving learning and memory functions in rodent models. Furthermore, JNJ-54082730 exhibits the ability to cross the blood-brain barrier, making it a valuable tool for neuropharmacological research.
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