K-Opioid receptor agonist-1 is a potent agonist of the κ-opioid receptor, with a binding affinity (Ki) of 0.25 nM and an effective concentration (EC50) of 2 nM. This compound effectively crosses the blood-brain barrier, demonstrating brain/plasma ratios between 0.50 and 0.65. K-Opioid receptor agonist-1 shows significant anti-inflammatory properties in various dermatitis models, including those induced by arachidonic acid and oxazolidinone, making it a valuable tool for studying pain modulation and inflammation pathways.
K-Opioid receptor agonist-1 is a potent agonist of the κ-opioid receptor, with a binding affinity (Ki) of 0.25 nM and an effective concentration (EC50) of 2 nM. This compound effectively crosses the blood-brain barrier, demonstrating brain/plasma ratios between 0.50 and 0.65. K-Opioid receptor agonist-1 shows significant anti-inflammatory properties in various dermatitis models, including those induced by arachidonic acid and oxazolidinone, making it a valuable tool for studying pain modulation and inflammation pathways.
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