K-Ras(G12C) inhibitor 6

Catalog No.: A14103

K-Ras(G12C) inhibitor

K-Ras(G12C) inhibitor 6

K-Ras(G12C) inhibitor 6 Chemical Structure

CAS NO. 2060530-16-5

K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $180.00

Special Price $144.00

25 mg

Regular Price: $350.00

Special Price $280.00

50 mg

Regular Price: $600.00

Special Price $480.00

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Biological Activity

K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP.
In vitro DMSO 75 mg/mL (185.03 mM)
Water Insoluble
Ethanol 28 mg/mL (69.08 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.67 mL 123.35 mL 246.71 mL
0.5 mM 4.93 mL 24.67 mL 49.34 mL
1 mM 2.47 mL 12.34 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

*The above data is based on the productmolecular weight 405.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14103
Actions Inhibitor
CAS No. 2060530-16-5
Formula C17H22Cl2N2O3S
M. Wt 405.34
Purity >98%
SMILES C1CN(CCC1NC(=O)CCCS)C(=O)COC2=C(C=C(C=C2)Cl)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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