KDM4-IN-4 is a potent inhibitor of histone lysine demethylase 4 (KDM4), specifically targeting the Tudor domain of KDM4A with a binding affinity of approximately 80 µM. This compound demonstrates the ability to inhibit the interaction of H3K4Me3 with the Tudor domain in cellular contexts, exhibiting an EC50 value of 105 µM. KDM4-IN-4 is utilized in anticancer research to explore its role in epigenetic regulation and potential therapeutic applications.
KDM4-IN-4 is a potent inhibitor of histone lysine demethylase 4 (KDM4), specifically targeting the Tudor domain of KDM4A with a binding affinity of approximately 80 µM. This compound demonstrates the ability to inhibit the interaction of H3K4Me3 with the Tudor domain in cellular contexts, exhibiting an EC50 value of 105 µM. KDM4-IN-4 is utilized in anticancer research to explore its role in epigenetic regulation and potential therapeutic applications.
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