KDM5-C49 is a potent and selective inhibitor of KDM5 demethylases, exhibiting IC50 values of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C, respectively. This compound plays a critical role in epigenetic research, particularly in the study of cancer biology. It provides valuable insights into the mechanisms of gene regulation and the potential therapeutic strategies targeting KDM5 demethylases in cancer treatment.
KDM5-C49 is a potent and selective inhibitor of KDM5 demethylases, exhibiting IC50 values of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C, respectively. This compound plays a critical role in epigenetic research, particularly in the study of cancer biology. It provides valuable insights into the mechanisms of gene regulation and the potential therapeutic strategies targeting KDM5 demethylases in cancer treatment.
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