KDOAM-25 is a selective inhibitor of histone lysine demethylases 5 (KDM5) with reported IC50 values of 71 nM, 19 nM, 69 nM, and 69 nM for KDM5A, KDM5B, KDM5C, and KDM5D, respectively. This compound enhances global H3K4 methylation at transcriptional start sites, thereby modulating gene expression. KDOAM-25 demonstrates potential in addressing proliferative disorders, particularly in multiple myeloma cell lines such as MM1S, making it a valuable tool for investigating epigenetic regulation and its implications in cancer research.
KDOAM-25 is a selective inhibitor of histone lysine demethylases 5 (KDM5) with reported IC50 values of 71 nM, 19 nM, 69 nM, and 69 nM for KDM5A, KDM5B, KDM5C, and KDM5D, respectively. This compound enhances global H3K4 methylation at transcriptional start sites, thereby modulating gene expression. KDOAM-25 demonstrates potential in addressing proliferative disorders, particularly in multiple myeloma cell lines such as MM1S, making it a valuable tool for investigating epigenetic regulation and its implications in cancer research.
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