KF26777 (free base) is a highly selective antagonist of the adenosine A3 receptor, exhibiting a Ki value of 0.2 nM. It demonstrates significant selectivity over adenosine A1, A2A, and A2B receptors, with factors of 9000-fold, 2350-fold, and 3100-fold, respectively. This compound effectively inhibits [125I]AB-MECA binding to adenosine A3 receptors and holds potential for research into brain ischemia and inflammatory diseases, such as asthma.
KF26777 (free base) is a highly selective antagonist of the adenosine A3 receptor, exhibiting a Ki value of 0.2 nM. It demonstrates significant selectivity over adenosine A1, A2A, and A2B receptors, with factors of 9000-fold, 2350-fold, and 3100-fold, respectively. This compound effectively inhibits [125I]AB-MECA binding to adenosine A3 receptors and holds potential for research into brain ischemia and inflammatory diseases, such as asthma.
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