Kira8 (AMG-18)

Catalog No.: A18641

mono-selective IRE1α inhibitor

Kira8 (AMG-18)

Kira8 (AMG-18) Chemical Structure

CAS NO. 1630086-20-2

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

Availability: Out of stock

Package Price
5 mg
$200.00
10 mg
$320.00
50 mg
$1,000.00
100 mg
$1,480.00
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Biological Activity

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.64 mL 83.18 mL 166.36 mL
0.5 mM 3.33 mL 16.64 mL 33.27 mL
1 mM 1.66 mL 8.32 mL 16.64 mL
5 mM 0.33 mL 1.66 mL 3.33 mL

*The above data is based on the productmolecular weight 601.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18641
Actions Inhibitor
CAS No. 1630086-20-2
Formula C31H29ClN6O3S
M. Wt 601.12
Purity >98%
Synonyms AMG 18, AMG18
SMILES O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[[email protected]@H]6CNCCC6)=NC=C5)C3=CC=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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